After 14 seasons and 312 episodes, it's safe to say that Grey's Anatomy is a power house of a show with a huge following. Fans are always looking for clues that Shonda Rhimes may have left, letting us know what could be to come in the next episodes.

Fans of Grey's Anatomy have learned to pay close attention to every single detail in the show, because sometimes even the littlest things can predict huge events later on. The special 300th episode was full of Easter eggs and nods back to previous seasons, but similar moments are sprinkled all throughout the show - even going back as far as season 1.

Was Derek's ing planned from the start? Will Christina Yang ever come back? Did you know that one episode of Grey's Anatomy was actually a social experiment on the audience? Shonda Rhimes and Grey's Anatomy just keeps us guessing and surprises the fans with new information at every turn.

Here are 15 Little Things Fans Completely Missed In Grey's Anatomy.

15. Karev's CGI Appearance

Believe it or not, Grey's Anatomy was almost didn't include fan favorite Alex Karev. He's one of only 4 characters who have made it through all 14 seasons - along with Meredith Grey, Miranda Bailey, and Richard Weber - but Karev almost wasn't a character on the show at all.

When the pilot episode was shot, Karev wasn't even present. He had to be digitally added into the episode later, a detail hard to ignore after seeing it. Apparently the writers realized they wanted a male who could play the opposite of George O'Malley.

Karev's "rough around the edges" character was the perfect opposite to the nervous, shy O'Malley. It's a good thing the writers decided to add him, because at this point it's hard to picture what Grey's Anatomy would be without Karev.

14. "Dream A Little Dream Of Me"

The episode titled "Dream a Little Dream of Me" is the first episode of the fifth season of Grey's Anatomy. There are many things about this episode, including the title name, that may have foreshadowed Derek Shepherd's eventual ing later in the series.

In this episode, Meredith is having vivid dreams of Derek losing his life in an accident. As most fans know, Derek does eventually from complications related to a car accident in season 11. Not only did Meredith's dreams predict how Derek would leave, 6 seasons ahead of time, she even says at one point in the episode, "It's the nightmares that always seem to become reality. The person that invented the phrase 'Happily ever after' should have his a-- kicked, so hard!"

Did the writers really know this early how Derek's life would end, and that they wouldn't get their "happily ever after," or was it all one big coincidence?

13. Christina Yang's Article

Ever since fan favorite Christina Yang left the show on the season 10 finale, everyone has been wondering if she'll make a return. Without her "person", Meredith just hasn't been the same, and people have been speculating for a while now that Yang will make a comeback.

We may have gotten a hint of her return in a recent episode where Meredith asks Teddy if she's read Christina's latest article.

The camera then briefly cuts to a shot of the article along with Christina's picture, which was definitely quick and easy to miss if you looked away even for a second. It could just be a way of keeping Christina relevant in Meredith's life - we like to think they stay in way more than the show lets on - or it could be an actual hint that we may be seeing more of Christina again soon.

12. The Original 5

For a group of best friends who are interning at the same hospital, these five sure have been through their share of tragedies. It's understandable that as surgical interns you deal with other people's tragedies every day, but have you ever noticed that all of the original five had surgical complications of their own?

In season 1 Christina had her ectopic pregnancy, and George was dragged under a bus trying to save someone and ed after several surgeries. Izzy is the easiest to , also going through several surgeries for her cancer. Then we have Karev, who survived a gunshot wound to the chest, and Meredith, who needed and emergency c-section as well as surgery after the fact on her spleen.

In reality, five interns at the same hospital all getting surgery within a couple years of each other would be pretty rare, but maybe the show just doesn't want us to be happy.

11. Jo's Legal Name

Jo has always been a complicated character. At first she comes off as a bit neurotic and annoying, but eventually we find out about her complicated past and why she is the way she is. One detail of her previous life we discover is her name, which is really Brooke.

Jo uses an alias to hide from her crazy ex, but what's never actually clear is whether or not Jo actually legally changed her name.

The issue comes up when she is asked to testify in court about Karev's assault on the intern Andrew Deluca. It didn't actually make sense why Jo was afraid of testifying.

Had she legally changed her name, she could have testified under her new name, and her ex would never find her. If she hadn't legally changed her name, it seems strange that nobody would know her real name - not even the heads of the hospital who hired her.

10. The Gang's Doppelgangers

There were plenty of Easter eggs in the 300th episode of Grey's Anatomy that fans caught on to. The main callback of the episode to previous seasons was that doppelgangers of George, Christina, and Izzy all come into the hospital that day for treatment.

Though it was clear that they looked like Meredith's old friends, the details go even further.

Most fans may not have noticed that the doppelgangers not only looked like George, Christina, and Izzy, but they were wearing similar clothes to what the originals wore in the pilot episode. George had on a brown coat, Christina had on a leather jacket, and Izzy wore a pink/purple sweater. This small detail just added more to the nostalgia, making us miss our favorite interns even more.

9. April Is Actually Pregnant

Most times when actors get pregnant, it doesn't coincide with the characters they play on TV. This often leads to awkward pregnancy cover-ups, and sometimes even absences from the show for a time.

In Sarah Drew's case, her character April Kepner had a pregnancy story arc while she was carrying a baby in real life.

In fact, only 10 hours after she fake delivered her baby on the show, Drew actually went into labor and delivered her own baby girl. Talk about perfect timing!

Drew talked to The Hollywood Reporter about how strange and special her pregnancy journey was. She said, "I was watching the episode last week and got super emotional just looking at my belly because I didn't know my daughter's name yet, I didn't know she was girl yet and there I am looking at my belly with her inside of me and there was something so crazy weird about seeing that. It was emotionally intense [shooting that] for sure."

8. Amelia's Sly Diss

In another one of those "blink and you might miss it" moments, the writers threw in a little political joke into an otherwise serious situation. As most fans know, Amelia Shepherd, Derek's sister and skilled brain surgeon, at one point had a brain tumor of her own.

The tumor almost completely destroys her relationships and her life, until finally it is removed by her friend and old colleague Tom Koracick. Amelia's recovery is slow and concerning at first, but thankfully she eventually gets better.

When Tom is clearing Amelia for release, he asks her a few general questions including, "where are you" and "what year is it" to test her thinking abilities. When he asks her if she knows who the current president is, Amelia says "I wish I didn't."

7. Derek's Final Wish

There are so many references to Derek's ing early on in the series that come true, it's easy to wonder if the writers knew all along what would happen to him. Back in season 1, Derek tells Meredith that if he is ever in a coma or on his last legs that he wants nothing more than for his sisters to be by his side for his final moments.

Fast forward to season 11, where this is exactly the case, and Meredith doesn't honor his wishes. Did she not , or just not care? Either way it's hard to see Derek go without the family by his side that he wanted.

In the most recent season, Derek's sister Amelia actually brings up to Meredith that she regrets and is even angry about not being there for Derek's last moments. It's as if she knew he would have wanted her there - which he did.

6. M.A.G.I.C.

If Meredith Grey is known for one thing on Grey's Anatomy, it's her beginning and end of the show voiceovers. Her reflective monologues always make us think about what we just saw, or what's to come, but in the 300th episode final voiceover, something even more special was thrown in.

While Meredith is looking up at the observation room and seeing her late mother Ellis Grey clapping and finally being proud of her, Meredith mentions "magic," which could easily be interpreted as talking about her surgical success or seeing her mother. This may be true, but we also have to take into consideration the doppelgangers of her friends who appear in this episode.

When Meredith says, "we are forced to acknowledge that certain kinds of magic exists," it turns out she may have been referring to the original five. MAGIC is an acronym for their names: Meredith, Alex, George, Izzy, and Christina.