Handsome Jack is the most popular villain from the Aliens: Colonial Marines) developed the game, which proved to be such a hit it didn't take long for Borderlands 2 to arrive, which improved on the original in just about every way and is (arguably) the most popular entry.
Borderlands is now a full-blown franchise, with The House With A Clock With In Its Walls) is developing a movie adaptation.
Borderlands' most popular bad guy is Handsome Jack, who was a central character in three games. Jack was introduced in Borderlands 2 and is the CEO of the Hyperion Corporation. He grows from an egotistical irritant to full-blown villain by the game's finale, but what makes him a unique antagonist is his unwavering belief that he's the hero of the story and his evil deeds are justified. Jack wears a mask over his face to cover a scar, the origins of which were explained in Borderlands: The Pre-Sequel. He also appeared in hologram form in Tales From The Borderlands. Handsome Jack is voiced by actor Dameon Clarke, who has a prolific CV.
Dameon Clarke should be well known to fans of the How To Get Away With Murder.
One of the reasons Handsome Jack is so acclaimed is Dameon Clarke's excellent performance, infusing what should be a hateful villain with both humor and humanity. Clarke has been nominated for his work on the Borderlands series multiple times, including winning Best Performance by a Human Male at 2012 Spike Awards. Given Handsome Jack's ultimate fate in Borderlands 2 it's unlikely he was will serve as a primary villain in future games, though his presence was still felt in Borderlands 3.