The deaths of Richard and Mary Parker would forever affect their son Peter's life. Originally government agents who died in a plane crash while on mission, Hulk.
In a clone of Peter Parker, manipulated to look like Richard by his creator, Doctor Otto Octavius.
In Ultimate Origins, a prequel series set 15 years in the past, Bendis and artist Butch Guice told a different version of the Parkers' famous deaths contradicted what fans already knew about Peter's parents. Richard Parker was revealed to be among a brain trust along with Hank Pym, Bruce Banner, and Franklin Storm. The team is tasked with recreating Project Rebirth. Provided with a sample of Nick Fury's blood, Dr. Pym and Banner believe they've made a breakthrough and decide to test it, their guinea pig being Bruce himself. Around that time, Richard had an unexpected visit from his wife Mary and their newborn son Peter. Despite being warned last minute by a fleeing Hank Pym, Richard and Mary are killed by when Banner Hulks out and destroys the building, leaving Peter Parker an orphaned survivor.
The sight of the infant Peter is traumatic enough to cause the Hulk to revert back to Bruce Banner, who cannot believe the destruction he caused before he is knocked unconscious by Fury. Cradling the infant Peter in his arms, Fury apologizes for the tragic turn of events, stating that its fortunate that due to his age, he won't any of it. This scene contradicts anything Fury has told Peter throughout their tentative relationship, meaning that Fury lied to either protect Peter or out of guilt he felt for his assumed role in their death. This event also makes events in the Ultimate Spider-Man series, which showed Peter living with his parents as a child instead of only as a baby, impossible as well. The story highlighted Ultimate Marvel's issue with continuity, where events within separate series were either ignored or ret-conned by others despite happening within the same universe.
Whether or not it makes sense, Richard and Mary's death's ensured that Peter ended up with his Aunt May and Uncle Ben, confirming what Bruce Banner said to Peter years later during Ultimate Marvel Team Up, "Everything is connected." Whether or not Bruce Banner ever realized or owned up to unintentionally killing Spider-Man's parents, it would appear that Peter Parker's life was destined for tragedy, regardless of what universe it's in.
